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Creatine

Creatine treatment: how to optimize intake?

female squats

To be effective, creatine must be taken cyclically and regularly, alternating periods of 4 to 8 weeks with breaks of at least 4 weeks. We do not particularly recommend continuous intake, although this is not dangerous.

What's the point of a creatine cure?

Overview of creatine's effects

Creatine is a natural organic compound synthesized by the body from three amino acids: arginine, glycine and methionine. It plays a fundamental role in rapid energy production at cellular level.

In the muscles, creatine is converted into phosphocreatine, which rapidly regenerates ATP (Adenosine TriPhosphate), our main source of energy for muscle contractions. This mechanism is particularly important during high-intensity, short-duration physical exercise .

Creatine is not a doping product! It naturally improves performance without artificially modifying the body's functions.

An athlete will be able to slightly increase his or her natural creatine production, but without supplementation, reserves can only sustain maximum effort for 8 to 10 seconds. This is why many athletes seek to increase their creatine levels through appropriate supplementation.

Creatine's effects on performance are numerous:

  • Increased energy reserves for short-duration, high-intensity efforts: creatine monohydrate saturates muscle stocks of phosphocreatine
  • Increased training volume
  • Optimizing recovery
  • Enhanced maximum strength and stimulation of hypertrophy: creatine indirectly promotes muscle development by enabling more intense training sessions

What about weight loss?

Creatine has no direct effect on weight loss or muscle mass gain.

However, it does enable you to intensify your training, which can promote weight loss as part of a weight-loss program, or the development of muscle mass as part of a mass-gain program with creatine supplementation.

To achieve these benefits, creatine supplementation must follow a precise protocol. Scientific studies have shown that simply taking creatine once in a while has no effect: it's the gradual saturation of reserves that optimizes performance!

How to structure your creatine cure?

How long does an effective cure last?

Studies show that a period of 4 to 8 weeks is ideal for maximizing the benefits of supplementation.

For best results, we recommend the following cycle:

  • Active phase: 4 to 8 weeks of regular use
  • Break phase: minimum 4 weeks without creatine supplementation

Even though continuous creatine intake is not dangerous, alternating phases of intake and pause allows the body to maintain optimal sensitivity to the supplement.

Breaks between cycles are interesting for several reasons:

  • Allow the body to return to its natural metabolism
  • Avoid desensitization to the effects of creatine

It's best to synchronize intake cycles with periods of intensive training. For example, it's best to program a creatine cure during strength or mass phases, then take a break during endurance or maintenance phases.

Is a charging phase necessary?

Two main protocols are generally adopted by sportsmen and women: direct intake as a maintenance dose, or via an initial loading phase.

The loading phase protocol was developed by Professor Roger Harris:

  • Days 1 to 5: 20 grams of creatine per day, divided into 4 doses of 5 grams each.
  • From day 6: 3 to 5 grams daily as maintenance dose

Rather than capsules, the powder form of the dietary supplement allows you to adapt the dosage to the chosen protocol!

The protocol without loading phase, proposed by Professor Eric Hultman, recommends a direct intake of 3 to 5 grams a day for the duration of the cure.

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Loading phase (20g/day)
Maintenance phase (3-5g/day)

Here, in brief, are the advantages and disadvantages of the 2 protocols:

With load phaseWithout load phase
✅ Fast saturation (5 days)✅ Better digestive tolerance
✅ Ideal before a medium-term competition✅ Simple protocol
✅ Effects felt quickly✅ Lower cost
❌ Digestive disorders more likely❌ Slower saturation (30 days)
❌ Higher costs due to greater consumption

In fact, over the long term, both approaches deliver similar results. The choice will depend above all on the goals set and the digestive tolerance of each individual.

Creatine Creapure®

The best for maximizing muscle power in a healthy way and optimizing intensive performance

  • Standardised without doping substances
  • No additives, no sweeteners
  • Made in Germany, packaged by Protéalpes in Albertville

Is it really necessary to follow an intake protocol for creatine?

The importance of regularity

Regular intake is fundamental to optimize creatine's effects. Scientific studies show that daily intake is necessary to maintain creatine saturation of muscle reserves.

In fact, the body accumulates creatine day after day to reach an optimal level in the muscles. Irregular intake compromises this process.

👉 Don't forget to take your creatine on rest days! Studies show that muscle reserves decline rapidly without regular intake.

Does timing really matter?

Contrary to popular belief, the exact moment of intake is not decisive. Creatine has no immediate effect. It acts over the long term, gradually saturating muscle reserves.

Is continuous intake dangerous?

Scientific studies have shown no danger of continuous creatine intake on renal function in healthy people. However, we recommend cycling to avoid metabolic adaptation.

You have to be vigilant about the quality of your supplement! The certified creatine monohydrate Creapure® certified creatine monohydrate is the ultimate safety guarantee.

This pure supplement, with no additives or sweeteners, is produced in Germany under strict quality control.

How to optimize the effectiveness of your treatment? 

Before or after training?

A study published in the Journal of the International Society of Sports Nutrition compared pre- and post-workout creatine intake. The results show similar benefits, with better assimilation when creatine is taken post-training.1

Once again, timing is irrelevant: as long as you take creatine every day, your creatine reserves will be saturated within a few days.

During meals?

Creatine can be taken with meals, as carbohydrates tend to help its assimilation, but the primary objective is always the same: to take creatine regularly so that your reserves are always saturated.

Staying hydrated

It is essential to adapt hydration to the intensity of the session to optimize both the effects on training and the assimilation of the supplement.

Creatine works by attracting water into the muscles. That's why you may notice a slight weight gain at the start of a course of treatment; it's a natural intracellular water retention linked to the creatine treatment!

Combination with other supplements?

The creatine + whey protein mix is common among athletes. The combination of creatine and protein promotes muscle recovery and growth, thanks in particular to the complementary effect of these two nutrients:

  • Whey helps build muscle
  • Creatine increases maximum strength during training

Conclusion

In short, the success of a creatine cure depends on:

  • A suitable daily dose (3-5g/day in the maintenance phase)
  • Regular intake, even on days off
  • Alternating cycles of several weeks and breaks
  • Optimum hydration
  • Choosing a quality form of creatine (Creapure®-labeled monohydrate)

And above all, don't forget that taking this dietary supplement must be accompanied by appropriate training and balanced nutrition!

Further information

To deepen your knowledge of creatine cures and their applications, here are a few additional resources:

If you're fasting or observing Ramadan, our article on creatine and fasting explains how to adapt your supplementation protocol during these particular periods.

To understand how creatine influences your body at blood level, consult our guide to normal creatine levels in the blood.

Some people may experience digestive discomfort during a cure. Our detailed article on creatine and digestive problems offers practical solutions to minimize these side effects.

Wondering at what age creatine supplementation is recommended? Our At what age can you start creatine guide answers this important question for young athletes and their parents.

Do women have specific needs when it comes to supplementation? Find out in our article Should women take creatine? which discusses the particular benefits for female health.

Finally, if you're hesitating between different types of supplements, our BCAA vs creatine comparison will help you understand the specifics of each and make the choice best suited to your goals.

1The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength by

An article written by

Aymeric Mendez & Guillaume Lavastre

Guillaume and Aymeric are the founders of Protéalpes. They are also pharmacists with a passion for nutrition and sport.

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