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Thermogenesis: definition, weight loss, how it works

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Looking to lose weight effectively? Thermogenesis could be the key to boosting your metabolism. But what exactly is thermogenesis? Thermogenesis is the natural process by which our body produces heat. This fascinating mechanism plays a crucial role in our energy metabolism and the regulation of our body temperature. It directly influences our daily calorie expenditure and can have a significant impact on weight loss.

In this article, we'll explore in detail how thermogenesis works, its role in basal metabolism, and how to optimize it in a healthy way to achieve your fitness goals.

We will also try to demonstrate that dietary supplements claiming to "burn fat" should generally be avoided.

What is thermogenesis and how does it work?

Thermogenesis(1) is a fundamental physiological process by which the human body and those of other warm-blooded animals produce heat. This mechanism plays a crucial role in maintaining body temperature and regulating energy metabolism.

The human body uses several mechanisms to generate heat and maintain a stable internal temperature of around 37°C, regardless of variations in ambient temperature. These mechanisms fall into three main categories:

  • Shivering thermogenesis: this type of heat production is triggered by exposure to cold, and involves rapid, involuntary muscle contractions. These contractions increase muscle activity and, consequently, energy expenditure, thus generating heat.
  • Shiver-free thermogenesis: this process mainly involves brown adipose tissue, also known as brown fat. This specialized tissue contains numerous mitochondria rich in a protein called thermogenin (UCP1). Thermogenin enables the mitochondria to generate heat directly from fatty acid oxidation, bypassing ATP production.
  • Dietary thermogenesis: also known as the thermic effect of food, this corresponds to the increase in heat production following the ingestion of food. This increase is due to the energy expended in the digestion, absorption and metabolism of macronutrients (proteins, carbohydrates, lipids).

The central nervous system, in particular the hypothalamus, plays a crucial role in regulating thermogenesis. It receives signals about internal and external temperatures, and coordinates appropriate responses to maintain thermal equilibrium.

Boxing muscle training

Thermogenesis is influenced by various factors, including :

  • Physical activity: exercise increases heat production through muscular activity. 
  • Diet: certain foods and nutrients, such as proteins and caffeine, have a higher thermogenic effect. 
  • Hormones: thyroid hormones and catecholamines stimulate thermogenesis.
  • Exposure to cold : activates thermogenesis without shivering in brown adipose tissue.

It's important to note that thermogenic capacity varies between individuals and can be influenced by factors such as age, gender, muscle mass and amount of brown adipose tissue.

Understanding the mechanisms of thermogenesis has important implications in various fields, including physiology, nutrition and energy metabolism research. It also opens up interesting prospects for the development of strategies to increase energy expenditure, although the efficacy and safety of such approaches still require in-depth study.

With this in mind, let's take a look at the relationship between thermogenesis and weight loss.

What impact does thermogenesis have on weight loss?

Thermogenesis plays a crucial role in regulating body weight and fat loss. This natural process of heat production by the body directly influences our daily energy expenditure and basal metabolic rate.

Mechanisms of thermogenesis and weight loss

Thermogenesis contributes to weight loss in several ways:

  • Increased metabolism: the production of body heat stimulates the metabolic rate, resulting in increased calorie consumption, even at rest.
  • Fat oxidation: activating thermogenesis promotes lipolysis, the process of breaking down adipose tissue into fatty acids that can be used as an energy source.
  • Core temperature regulation: maintaining body temperature at 37°C requires constant energy expenditure, thus contributing to weight loss.
  • Thermal effect of food: dietary thermogenesis represents the energy expended to digest, absorb and metabolize macronutrients, particularly proteins.

Effectiveness of thermogenesis for weight loss

Although thermogenesis can help with weight loss, its impact remains (very) moderate. One study showed that an increase in thermogenesis can lead to an additional loss of around 0.5 kg of body fat over 8 weeks. However, the effect varies considerably between individuals and depends on factors such as genetics, age and lifestyle.

It's important to note that thermogenesis alone is not enough to induce significant weight loss. It must be combined with a balanced diet and regular physical activity to achieve lasting results.

How to stimulate thermogenesis naturally?

Naturally stimulating thermogenesis can help increase calorie expenditure and promote weight loss. Here are the main methods for activating thermogenesis in a natural and healthy way:

Optimizing your diet

Dietary thermogenesis, which represents the energy expended to digest and metabolize food, can be optimized by making the right nutritional choices:

Regular physical activity

Physical exercise is a powerful stimulant of thermogenesis:

  • Resistance training: the muscular contraction induced by weight training increases heat production.
  • High-intensity sessions: intense interval training (HIIT) is particularly effective for boosting post-exercise thermogenesis.
  • Daily activity: even low-intensity activities such as walking help to increase overall energy expenditure, both through mechanical effort and through related thermogenesis.

Other tips

Exposing the body to cold: exposure to cold activates thermogenesis without shivering, mainly via brown adipose tissue. Ambient temperature can be adjusted: maintaining a slightly cooler indoor temperature forces the body to produce more heat to maintain its temperature.

Optimizing sleep and stress :

Quality sleep and good stress management are essential for maintaining a hormonal balance conducive to thermogenesis. It is possible to :

  • Respect regular sleep schedules: a stable circadian rhythm promotes an efficient metabolism.
  • Practice relaxation techniques: chronic stress can disrupt metabolism and encourage fat storage.

In conclusion, stimulating thermogenesis naturally involves a global approach, combining a suitable diet, regular physical activity and healthy lifestyle habits. These natural methods, while less spectacular than some artificial solutions, offer lasting results that benefit overall health.

It's important to note that while these natural approaches are generally safe and beneficial, some people turn to more radical and sometimes unhealthy solutions to boost their metabolism.

Food supplements to promote thermogenesis 

Food supplements known as "fat burners " are very popular for weight loss. Their principle is to stimulate thermogenesis, i.e. the body's production of heat, thereby increasing energy expenditure and thus the number of calories burned each day.

In theory, increased thermogenesis would make it easier to create a calorie deficit, without reducing food intake, and therefore promote body fat loss over time, more easily. These supplements often contain ingredients such as caffeine and other stimulants that act on the nervous system and adrenergic receptors.

However, the real effectiveness of these "fat burners" remains highly debatable. While they may increase energy expenditure slightly in the short term, this effect is fairly weak and short-lived. Over the long term, their use does not appear to bring any significant weight-loss benefit compared to a hypocaloric diet alone, and the benefit/risk balance does not appear to be in their favor.

In fact, most of these supplements contain high doses of stimulants which are not without risk to health, especially in the event of over-consumption or prolonged use. They can have unpleasant (nervousness, palpitations, sleep disorders...) or even dangerous (hypertension, heart rhythm disorders...) side-effects.

Mind you, this doesn't mean that all nutritional supplements are bad or dangerous: whey, for example, can be a real asset to your recovery. But in the end, there are only a few classes of supplements that have proven to have a real healthy effect on sports performance.

In short, despite their tempting claims, fat burners are not a miracle solution for weight loss. Their benefit/risk ratio is rather unfavorable. A balanced diet and regular exercise remain the best, safest and healthiest ways to regulate weight over the long term. In cases of severe overweight, personalized medical follow-up is recommended.

The following table will give you an overview of the most important points in this article:

🔑 Key points📘 Description
🌡️ ThermogenesisBody heat production
❄️ ChillsHeat from muscle contractions
🧬 No chillsUsing brown fat
🍽️ FoodHeat from food digestion
🏃 Physical activityStimulates thermogenesis
🥩 ProteinsThermogenic foods
🥶 Cold exposureActivates brown fat
💤 SleepInfluences metabolism
🔥 Fat burner dietary supplementsQuestionable effectiveness, possible risks, ultra-processed products
🏋️ Natural strategiesDiet and exercise for lasting results

Sources :

1Fundamental mechanisms of thermogenesis by

An article written by

Aymeric Mendez & Guillaume Lavastre

Guillaume and Aymeric are the founders of Protéalpes. They are also pharmacists with a passion for nutrition and sport.

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