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nutrition

How and when should you take your pre-workout supplement?

Updated on February 16, 2026 (1 day ago) by the Protéalpes team of pharmacists

Two people on rowing machines in a gym, lit by a window, evoking effort and concentration.

Pre-workout supplements, commonly referred to as "pre-workouts," are often mentioned in the world of bodybuilding and high-level sports. 

These products, whose composition varies considerably depending on the brand, are primarily designed to optimize athletic performance. Caffeine, the key ingredient in these formulas, is scientifically recognized for its beneficial effects on muscle strength and endurance. 

Other classic ingredients such as citrulline, beta-alanine, and tyrosine are frequently found in these supplements, although their effects are less well documented. 

The timing of intake is important to maximize the effectiveness of these products, with significant variations depending on individual sensitivity and the formulation used. 

In this article, we will first examine the nature and composition of pre-workouts, then discuss two different methods and when to take them to optimize their benefits.

What is a pre-workout supplement?

A pre-workout supplement, as its name suggests, is a dietary supplement designed to be consumed before training. Although this is not the only formulation, it is generally marketed in powder form to be diluted in water. It promises to improve athletic performance, concentration, and energy during intense training sessions, particularly weight training.

A complex marketing reality

The pre-workout market is saturated with products of varying compositions and often exaggerated claims. Labels often display a long list of supposedly "revolutionary" ingredients, creating the illusion of a miracle formula. 

This marketing strategy can easily mislead consumers, especially beginners, who think they are buying a product with multiple scientifically proven benefits.

Caffeine: the only scientifically validated ingredient

Among the multitude of ingredients found in these supplements, caffeine is the only one whose effectiveness has been solidly established by scientific research(1). Its effects on the body are numerous and well documented:

  • Impact on the central nervous system: caffeine blocks adenosine receptors, a molecule responsible for feelings of fatigue. This action helps you stay more alert and delays feelings of fatigue during exercise.
  • Metabolic effects : It stimulates the production of adrenaline, which leads to:
    • An increase in heart rate
    • Better utilization of fats as an energy source
    • Improved muscle contraction
    • Increased alertness and concentration
  • Sports performanceStudies show that caffeine can:
    • Improve maximum strength
    • Increase muscular endurance
    • Reducing the perception of effort
    • Optimize endurance performance

Other ingredients commonly found in pre-workout supplements (citrulline malate, beta-alanine, creatine, BCAAs, taurine, etc.) do not have sufficient scientific support to justify their inclusion in a pre-workout formula. Although some of these components may have beneficial effects in other contexts, their effectiveness as pre-workout supplements has not been conclusively demonstrated by current scientific research.

This reality suggests that we should focus primarily on the dose, timing, and method of caffeine intake, which we will examine in detail in the next section.

How and when should it be taken? Two different methods

There are two main methods for taking a pre-workout supplement, each with its own characteristics in terms of effectiveness and duration of action. The choice of method will mainly depend on time constraints and personal preferences.

The classic method: dilution in water

This traditional approach involves diluting the pre-workout powder in water for standard oral consumption. The time it takes to take effect is relatively long, as the product must pass through the entire digestive system before being absorbed. The effects generally manifest after 45 to 60 minutes, with peak effectiveness between 60 and 90 minutes after consumption.

This duration can vary significantly depending on individual sensitivity to caffeine, fasting status, and individual metabolism.

For optimal effectiveness with this method, it is recommended to take the supplement on an empty stomach or between meals, while following the recommended dosage. It should be taken approximately one hour before the start of your workout to fully benefit from its effects during training.

The sublingual method: a faster alternative

Sublingual administration requires the use of products specifically designed for this route of administration. Sublingual pre-workouts are specially formulated for optimal absorption under the tongue.

This method involves holding the product under the tongue until the caffeine is absorbed. Absorption occurs directly through the sublingual mucosa, allowing the product to enter the bloodstream quickly.

The effects are felt in just 20-25 minutes, offering increased flexibility in timing of intake. This rapid action even allows for adjustment of intake during exercise if necessary.

An important warning about addiction

It is important to note that regular caffeine consumption can lead to a certain degree of addiction. The body gradually develops a tolerance, requiring larger doses to achieve the same stimulating effects. 

To avoid this phenomenon, and in order to avoid falling into a routine dependence on these products, we recommend not resorting to pre-workout consumption on a systematic basis. We believe it is wise to limit its use to the most intense or most structuring sessions in the context of progression, or during competitions.

This targeted and discontinuous approach will maintain the product's effectiveness over the long term while avoiding the establishment of potentially harmful automatic responses.

Caution: Regardless ofthe method chosen, it is essential not to exceed the recommended doses and to remain alert to any side effects. It is also advisable to avoid taking it late in the day to prevent sleep disturbances.

Conclusion

To optimize the effectiveness of a pre-workout supplement, it is crucial to follow the selection criteria and instructions for use. Managing the timing of intake, whether it be the traditional 30 to 60 minutes or 20 to 30 minutes sublingually, remains crucial for maximizing the effects on blood circulation and muscle recovery.

It is important to note that these supplements are just one tool among many for achieving goals related to strength, speed, or muscle mass gains. A balanced diet and structured training remain the foundations of sustainable progress. The key to success lies in the sensible use of pre-workouts, avoiding overconsumption, and taking breaks to maintain their long-term effectiveness.

Here is a table summarizing the key points of the article:

🌟 Key pointEssential summary
🥤 DefinitionPre-workout: supplement to boost energy and performance before training.
☕ Caffeine approvedOnly caffeine has proven effects on strength and endurance in this context.
⏳ Key timingOptimal intake: 30-60 minutes before (standard ingestion) or 20-25 minutes (sublingual).
🥛 Traditional methodDilution in water: effects in 45-60 min, peak at 60-90 min.
👅 Rapid sublingualAbsorption under the tongue: effects in 20-25 minutes, fast-acting.
⚠️ AddictionRisk of caffeine addiction: Reasonable spacing between doses recommended.

An article written by

Aymeric Mendez & Guillaume Lavastre

Guillaume and Aymeric are the founders of Protéalpes. They are also pharmacists with a passion for nutrition and sport.

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